The association study of polymorphic variants of hypothalamic-pituitary-adrenal system genes (AVPR1B, OXTR) and aggressive behavior manifestation: a focus on social environment

Background: Aggressive behavior (AB) represents an important social problem, which results in significant costs for the society. A role developing aggression is suggested to be mediated by molecular mechanisms related functioning of oxytocin (OXTR) and arginine vasopressin receptor (AVPR1B) genes involved regulation behavior. On other hand, a specificity environmental factors affecting individual at various stages development may modulate processes, especially gene expression level, thus human’s ability self-control resulting AB manifestation. The aim study: Considering multifactorial nature aggression, present study aimed estimate both genetic- haplotype-based effects OXTR AVPR1B gene-by-environment interactions AB. Materials methods: genotyping (rs2228485, rs53576) (rs33911258) variants was conducted via PCR with fluorescent detection 189 criminal offenders (7% women) from Republic Bashkortostan, who committed murders, control group (N=254, 12% corresponding ethnicity age. Statistical analysis performed logistic regression correction multiple comparisons (PLINK v.1.09). Results: As result statistical association rs2228485 A-allele AG haplotype (rs2228485 enhanced risk observed. In addition, we demonstrated modulating effect such as presence severe somatic diseases, alcohol addiction, fa milial history psychopathologies, income education level. Moreover, rs33911258 G-allele on Conclusion: data obtained evidence that examined combination specific affect neuronal systems functioning, manifestation antisocial